Glioma Stem Cells: A Midterm Exam
نویسندگان
چکیده
Several years ago, the discovery of a highly tumorigenic subpopulation of stem-like cells embedded within fresh surgical isolates of malignant gliomas lent support to a new paradigm in cancer biology--the cancer stem cell hypothesis. At the same time, these "glioma stem cells" seemed to resolve a long-standing conundrum on the cell of origin for primary cancers of the brain. However, central tenets of the cancer stem cell hypothesis have recently been challenged, and the cellular origins of stem-like cells within malignant glioma are still contended. Here, we summarize the issues that are still in play with respect to the cancer stem cell hypothesis, and we revisit the developmental origins of malignant glioma. Do glioma stem cells arise from developmentally stalled neural progenitors or from dedifferentiated astrocytes? Five separate predictions of a neural progenitor cell of origin are put to the test.
منابع مشابه
Improving performance in quantum mechanics with explicit incentives to correct mistakes
An earlier investigation found that the performance of advanced students in a quantum mechanics course did not automatically improve from midterm to final exam on identical problems even when they were provided the correct solutions and their own graded exams. Here, we describe a study, which extended over four years, in which upper-level undergraduate students in a quantum physics course were ...
متن کاملنحوه ارزشیابی دانشجویان توسط اعضاء هیأت علمی و کادر آموزشی دانشگاه علوم پزشکی شهرکرد در سال87-86
Introduction: Student evaluation is considered as one of the most important principles of educational planning. An effective evaluation not only plays an important role in discriminating among students, but also helps the instructor assess his own activities. Additionally, a suitable strategy for solving the problems of the educational program may be provided on the basis of evaluation. For thi...
متن کاملProblem Set 3 Midterm Exam
Solutions must be submitted at beginning of class on Wednesday, March 3, 2004. This is an open-book exam. Handwritten answers are fine as long as they are legible and organized. Please show all work. I've tried to leave space on this handout for your solutions. The midterm is worth 15% of your total grade.
متن کاملCS 262A Midterm Exam SOLUTIONS
This exam is open book-feel free to consult any textual references you deem appropriate. These questions should be answerable with a combination of the class readings, class notes, and some thinking; there is no reason to consult any additional material. (Doing so may simply confuse things!) You are not allowed to discuss the questions with anyone! Submit your answers as a PDF file using the Mi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Neuron
دوره 58 شماره
صفحات -
تاریخ انتشار 2008